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KMID : 0816120000030010023
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Korean Journal of Pediatric Gastroenterolology and Nutrition
2000 Volume.3 No. 1 p.23 ~ p.29
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The Effect of 2-Week Dual Therapy with Proton Pump Inhibitor and Amoxicillin in the Eradication of Helicobacter pylori Infection for Treatment of Children with Recurrent Abdominal Pain
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Lee Young-Mock
Chung Ki-Sup
Lee Chang-Han
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Abstract
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Purpose : It has recently been recognized that Helicobacter pylori (H. pylori) is an
important factor in the pathogenesis of recurrent abdominal pain (RAP) in children. But,
the best treatment for H. pylori infection is still unsettled. This study was performed to
evaluate the efficacy of 2 weeks dual therapy with proton pump inhibitor (PPI) and
amoxicillin for children with H. pylori infection associated with RAP.
Method : Our study included 24 children with RAP who were H. pylori positive
assessed by CLO test and histologic examination (silver stain). We used the regimen
consisted of PPI (omeprazole, 0.7 ㎎/㎏/day) and amoxicillin (50 ㎎/㎏/day) for 2 weeks
to eradicate H. pylori. Eradication of H. pylori was determined 4 weeks after the
termination of treatment using the CLO test and histologic examination.
Results : The endoscopic diagnoses of patients were nodular gastritis in 11 cases,
superficial gastritis in 7 cases, peptic ulcer in 4 cases and normal finding in 2 cases. H.
pylori was eradicated in 12 cases by omeprazole and amoxicillin dual therapy for 2
weeks and the eradication rate was 50%. In 4 of 12 children in whom H. pylori had not
been eradicated with that regimen, we successfully eradicated H. pylori with other
regimens of which 2 or 3 drugs among omeprazole, amoxicillin, clarithromycin, colloidal
bismuth subcitrate (Denol ) and metronidazole were used.
Conclusion : The dual therapy with PPI and amoxicillin for 2 weeks had no clear
advantage over other regimens for the eradication of H. pylori infection in children. We
concluded that the combination of PPI and amoxicillin for 2 weeks is not so good for H.
pylori eradicated other commonly used regimens.
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KEYWORD
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Recurrent abdominal pain, Helicobacter pylori, Eradication, Proton Pump Ingibitor, Amoxicillin,
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